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KMID : 0605620100170040218
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Journal of Korean Society of Biological Psychiatry
2010 Volume.17 No. 4 p.218 ~ p.225
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The Impact of Choline Acetyltransferase Polymorphism on the Expression of Mild Cognitive Impairment
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Lee Jung-Jae
Park Joon-Hyuk
Lee Seok-Bum
Huh Yoon-Seok
Kim Tae-Hui
Youn Jong-Chul
Jhoo Jin-Hyeong
Lee Dong-Young
Park Kyoung-Un
Kim Ki-Woong
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Abstract
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Objectives: The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample.
Methods: We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI.
Results: The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No significant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055).
Coclusion: The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE epsilon4 allele was not significant with regard to the development of MCI.
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KEYWORD
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Choline acetyltransferase, Apolipoprotein E, Polymorphism, Gene-gene interaction, Mild cognitive impairment(MCI)
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